In clinical research, safety is ALWAYS the first priority.  The fundamental purpose of research is to determine if a new product is safe THEN is it effective.  Here's why you can be reassured of this.  First, any product tested by us has already been through a number of prior studies and tests to ensure it is safe to try on patients.  Second, numerous tests are done DURING the study to ensure YOUR safety - laboratory testing of blood and urine specimens, electrocardiograms, x-rays, physical examinations and any other specific tests that may be necessary for a given treatment.  Most importantly, at each visit, you, the patient are asked about any signs or symptoms you may be having and we determine if they could be caused by the treatment.  If we have any concerns that the treatment is bad for you or your health, we stop the treatment.  Additionally, if you have any concerns about a treatment you can always stop and no reason needs to be given.  We will not blame you or hold it against you.  More about this next time.